Differences in Proliferative Activity between Normoblasts and Pernicious Anemia Megaloblasts
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منابع مشابه
Differences in Proliferative Activity between Normoblasts and Pernicious Anemia Megaloblasts.
By E. G. RONDANELLI, P. Gomi n, E. MAGLIULO AND C. P. Fiom T HERE are numerous conflicting concepts19 regarding the proliferation rate of pernicious anemia (p.a. ) erythropoietic cells, compared with their normal counterparts; some authors1#{176} claim that megaloblasts proliferate at a lower rate than normoblasts, while others7’#{176}affirm quite the opposite. The proliferation rate of a cell ...
متن کاملMicrospectrophotometric determination of desoxyribosenucleic acid in megaloblasts of pernicious anemia.
By EDWARD II. REISNER JR., M.D. AND ROY KORSON, M.D.* W ITt! THE ISOLATION of vitamin B12’ an(l its (lemonstration as the ad-ti\’e anti-pci-md-ions anemia substance of liver,2 attention ‘as focused on some of its biochemical properties. It was shown that in the growth redluirements of various micro-organisms, vitamin B12 could be replaced by various desoxyribosides,4 5 from which evidence its r...
متن کاملProliferation of megaloblasts in pernicious anemia as observed from nucleic acid metabolism.
M EGALOBLASTIC ANEMIA is due chiefly to deficiency of vitamin B12 ( B12 ), of folic acid, or of both. Recent studies3’4’12’22 have been focused on the view that the metabolic defect leading to megaloblastosis may, in some way, be related to nucleic acid metabolism. However, the role of B12 coenzymes in mammalian nucleic acid metabolism has not been elucidated, nor are there exact data on the na...
متن کاملErythrokinetics in pernicious anemia.
T HE climmical emitity, permmicious anenmia, is the result. of a prolousged deficiency jut vitamimm 1312. While there is a gemmeral abnornmality throughout the body ins cellular growth ammd immetabolismmm,’ the effects of the deficiemmcy are readily denmoumstrated by the nmegaloblast.ic changes of the erythron. The mmmaummmer iui ivhich ammemia is produced seems imicreasingly complex as nmore d...
متن کاملPernicious anemia in childhood.
Two children from different families with pernicious anemia are described. The defect appears to be the lack of intrinsic factor in the acid gastric juice. The correct diagnosis and proper therapy are essential for insuring a normal growth and development. Studies performed in other members of both families failed to reveal any hematologic disorder. The prolonged and close follow-up of the firs...
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ژورنال
عنوان ژورنال: Blood
سال: 1964
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v24.5.542.542